| EC |
2.3.1.45 |
| Accepted name: |
N-acetylneuraminate 9-O-acetyltransferase |
| Reaction: |
acetyl-CoA + CMP-N-acetyl-β-neuraminate = CoA + CMP-N-acetyl-9-O-acetyl-β-neuraminate
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| Other name(s): |
N-acetylneuraminate 7(8)-O-acetyltransferase; sialate O-acetyltransferase; N-acetylneuraminate 7,8-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase; glycoprotein 7(9)-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase; N-acetylneuraminate O7-(or O9-)acetyltransferase; acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase; CASD1; acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase; N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
| Systematic name: |
acetyl-CoA:CMP-N-acetyl-β-neuraminate 9-O-acetyltransferase |
| Comments: |
The enzyme, found in animals, is essential for the formation of acetylated sialoglycans. The acetyl group has been shown to spontaneously move between the 9-O, 8-O, and 7-O positions of the neuraminate, with 9-O acetylation being most favoured. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 9054-50-6 |
| References: |
| 1. |
Schauer, R. Biosynthese von N-Acetyl-O-acetylneuraminsaüren. I. Inkorporation von [14C]Acetate in Schnitte der Unterkieferspeicheldrüse von Rind und Pferd. Hoppe-Seyler's Z. Physiol. Chem. 351 (1970) 595–602. [PMID: 5446640] |
| 2. |
Schauer, R. Biosynthese von N-Acetyl-O-acetylneuraminsaüren. II. Untersuchungen über Substrat und intracelluläre Lokalisation der Acetyl-coenzym A: N-acetylneuraminat-7- and 8-O-acetyltransferase von Rind. Hoppe-Seyler's Z. Physiol. Chem. 351 (1970) 749–758. [PMID: 5425947] |
| 3. |
Baumann, A.M., Bakkers, M.J., Buettner, F.F., Hartmann, M., Grove, M., Langereis, M.A., de Groot, R.J. and Muhlenhoff, M. 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. Nat. Commun. 6:7673 (2015). [DOI] [PMID: 26169044] |
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| [EC 2.3.1.45 created 1972, modified 2024] |
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