ExplorEnz: EC 2.3.1.283

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2.3.1.283

Accepted name:

2′-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

Reaction:

a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2′-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose = a 3′-(hydroxy)phthioceranyl-2′-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose + holo-[(hydroxy)phthioceranic acid synthase]

Other name(s):

papA1 (gene name)

Systematic name:

(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2′-acyl-2-O-sulfo-α,α-trehalose 3′-(hydroxy)phthioceranyltransferase

Comments:

This mycobacterial enzyme catalyses the acylation of 2′-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose at the 3′ position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Bhatt, K., Gurcha, S.S., Bhatt, A., Besra, G.S. and Jacobs, W.R., Jr. Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis. Microbiology 153 (2007) 513–520. [PMID: 17259623]
2.	Kumar, P., Schelle, M.W., Jain, M., Lin, F.L., Petzold, C.J., Leavell, M.D., Leary, J.A., Cox, J.S. and Bertozzi, C.R. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc. Natl. Acad. Sci. USA 104 (2007) 11221–11226. [PMID: 17592143]

[EC 2.3.1.283 created 2019]