ExplorEnz: EC 2.3.1.265

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2.3.1.265

Accepted name:

phosphatidylinositol dimannoside acyltransferase

Reaction:

(1) an acyl-CoA + 2,6-di-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-α-D-mannosyl)-6-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol
(2) an acyl-CoA + 2-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-α-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

Other name(s):

PIM2 acyltransferase; ptfP1 (gene name)

Systematic name:

acyl-CoA:2,6-di-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol acyltransferase

Comments:

The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Svetlikova, Z., Barath, P., Jackson, M., Kordulakova, J. and Mikusova, K. Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid—monoacylated phosphatidylinositol dimannoside. Protein Expr. Purif. 100 (2014) 33–39. [DOI] [PMID: 24810911]

[EC 2.3.1.265 created 2017]