ExplorEnz: EC 2.3.1.264

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2.3.1.264

Accepted name:

β-lysine N⁶-acetyltransferase

Reaction:

acetyl-CoA + (3S)-3,6-diaminohexanoate = CoA + (3S)-6-acetamido-3-aminohexanoate

Glossary:

(3S)-3,6-diaminohexanoate = β-L-lysine
(3S)-6-acetamido-3-aminohexanoate = N⁶-acetyl-β-L-lysine

Other name(s):

ablB (gene name)

Systematic name:

acetyl-CoA:(3S)-3,6-diaminohexanoate N⁶-acetyltransferase

Comments:

The enzyme is found in some methanogenic archaea and bacteria. In archaea it is induced under salt stress. The product, N⁶-acetyl-β-L-lysine, serves as a compatible solute, conferring high salt resistance on the producing organisms.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Pfluger, K., Baumann, S., Gottschalk, G., Lin, W., Santos, H. and Muller, V. Lysine-2,3-aminomutase and β-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of N^ε-acetyl-β-lysine and growth at high salinity. Appl. Environ. Microbiol. 69 (2003) 6047–6055. [DOI] [PMID: 14532061]
2.	Muller, S., Hoffmann, T., Santos, H., Saum, S.H., Bremer, E. and Muller, V. Bacterial abl-like genes: production of the archaeal osmolyte N(ε)-acetyl-β-lysine by homologous overexpression of the yodP-kamA genes in Bacillus subtilis. Appl. Microbiol. Biotechnol. 91 (2011) 689–697. [DOI] [PMID: 21538109]

[EC 2.3.1.264 created 2017]