ExplorEnz: EC 2.3.1.247

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2.3.1.247

Accepted name:

(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase

Reaction:

(5S)-5-amino-3-oxohexanoate + acetyl-CoA = acetoacetate + L-3-aminobutanoyl-CoA

For diagram of lysine catabolism, click here

Glossary:

L-3-aminobutyryl-CoA = (3S)-3-aminobutanoyl-CoA

Other name(s):

kce (gene name); 3-keto-5-aminohexanoate cleavage enzyme

Systematic name:

(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase

Comments:

Requires Zn²⁺. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, belongs to a class of enzymes known as β-keto acid cleavage enzymes (BKACE). It is involved in the anaerobic fermentation of lysine. cf. EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Barker, H.A., Kahn, J.M. and Hedrick, L. Pathway of lysine degradation in Fusobacterium nucleatum. J. Bacteriol. 152 (1982) 201–207. [PMID: 6811551]
2.	Kreimeyer, A., Perret, A., Lechaplais, C., Vallenet, D., Medigue, C., Salanoubat, M. and Weissenbach, J. Identification of the last unknown genes in the fermentation pathway of lysine. J. Biol. Chem. 282 (2007) 7191–7197. [DOI] [PMID: 17166837]
3.	Bellinzoni, M., Bastard, K., Perret, A., Zaparucha, A., Perchat, N., Vergne, C., Wagner, T., de Melo-Minardi, R.C., Artiguenave, F., Cohen, G.N., Weissenbach, J., Salanoubat, M. and Alzari, P.M. 3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation. J. Biol. Chem. 286 (2011) 27399–27405. [DOI] [PMID: 21632536]

[EC 2.3.1.247 created 2015, modified 2024]