| EC |
2.3.1.237 |
| Accepted name: |
neocarzinostatin naphthoate synthase |
| Reaction: |
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+ |
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For diagram of polyketides biosynthesis, click here |
| Other name(s): |
naphthoic acid synthase; NNS; ncsB (gene name) |
| Systematic name: |
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid-forming) |
| Comments: |
A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Sthapit, B., Oh, T.J., Lamichhane, R., Liou, K., Lee, H.C., Kim, C.G. and Sohng, J.K. Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus. FEBS Lett. 566 (2004) 201–206. [DOI] [PMID: 15147895] |
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| [EC 2.3.1.237 created 2014] |
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