ExplorEnz: EC 2.3.1.217

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2.3.1.217

Accepted name:

curcumin synthase

Reaction:

feruloyl-CoA + feruloylacetyl-CoA + H₂O = 2 CoA + curcumin + CO₂

For diagram of curcumin biosynthesis, click here

Glossary:

curcumin = (1E,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one
feruloylacetyl-CoA = feruloyl-diketide-CoA

Other name(s):

CURS; CURS1 (gene name); CURS2 (gene name); CURS3 (gene name)

Systematic name:

feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming)

Comments:

A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC 2.3.1.219, demethoxycurcumin synthase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Katsuyama, Y., Kita, T., Funa, N. and Horinouchi, S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J. Biol. Chem. 284 (2009) 11160–11170. [DOI] [PMID: 19258320]
2.	Katsuyama, Y., Kita, T. and Horinouchi, S. Identification and characterization of multiple curcumin synthases from the herb Curcuma longa. FEBS Lett. 583 (2009) 2799–2803. [DOI] [PMID: 19622354]
3.	Katsuyama, Y., Miyazono, K., Tanokura, M., Ohnishi, Y. and Horinouchi, S. Structural and biochemical elucidation of mechanism for decarboxylative condensation of β-keto acid by curcumin synthase. J. Biol. Chem. 286 (2011) 6659–6668. [DOI] [PMID: 21148316]

[EC 2.3.1.217 created 2013]