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Your query returned 1 entry. Printable version
EC | 2.3.1.182 | ||||
Accepted name: | (R)-citramalate synthase | ||||
Reaction: | acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate | ||||
Glossary: | (-)-citramalate = (2R)-2-methylmalate = (2R)-2-hydroxy-2-methylbutanedioate α-ketoisovalerate = 3-methyl-2-oxobutanoate α-ketobutyrate = 2-oxobutanoate α-ketoisocaproate = 4-methyl-2-oxopentanoate α-ketopimelate = 2-oxohexanoate α-ketoglutarate = 2-oxoglutarate |
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Other name(s): | CimA | ||||
Comments: | One of the enzymes involved in a novel pyruvate pathway for isoleucine biosynthesis that is found in some, mainly archaeal, bacteria [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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