ExplorEnz: EC 2.3.1.170

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2.3.1.170

Accepted name:

6′-deoxychalcone synthase

Reaction:

3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H⁺ = 4 CoA + isoliquiritigenin + 3 CO₂ + NADP⁺ + H₂O

For diagram of daidzein biosynthesis, click here

Glossary:

isoliquiritigenin = 4,2′,4′-trihydroxychalcone
liquiritigenin = 7,4′-dihydroxyflavanone

Systematic name:

malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)

Comments:

Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 114308-23-5

References:

1.	Ayabe, S., Udagawa, A. and Furuya, T. NAD(P)H-dependent 6′-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. Arch. Biochem. Biophys. 261 (1988) 458–462. [DOI] [PMID: 3355160]

[EC 2.3.1.170 created 2004]