The Enzyme Database

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Accepted name: acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase
Reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-α-D-glucosamine = an [acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-α-D-glucosamine
For diagram of lipid IVA biosynthesis, click here
Glossary: tetradecanoyl = myristoyl
Other name(s): UDP-N-acetylglucosamine acyltransferase; uridine diphosphoacetylglucosamine acyltransferase; acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase; (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase
Systematic name: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein]:UDP-N-acetyl-α-D-glucosamine 3-O-(3-hydroxytetradecanoyl)transferase
Comments: Involved with EC (lipid-A-disaccharide synthase) and EC (tetraacyldisaccharide 4′-kinase) in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Escherichia coli.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 105843-69-4
1.  Anderson, M.S., Bulawa, C.E. and Raetz, C.R.H. The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli. J. Biol. Chem. 260 (1985) 15536–15541. [PMID: 3905795]
[EC created 1990]

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