| EC |
2.1.3.12 |
| Accepted name: |
decarbamoylnovobiocin carbamoyltransferase |
| Reaction: |
carbamoyl phosphate + decarbamoylnovobiocin = phosphate + novobiocin |
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For diagram of novobiocin biosynthesis, click here |
| Glossary: |
decarbamoylnovobiocin = N-{7-[(6-deoxy-5-methyl-4-O-methyl-β-D-gulopyranosyl)oxy]4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methyl-2-buten-1-yl)benzamide
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| Other name(s): |
novN (gene name) |
| Systematic name: |
carbamoyl phosphate:decarbamoylnovobiocin 3′′-O-carbamoyltransferase |
| Comments: |
The enzyme catalyses the last step in the biosynthesis of the aminocoumarin antibiotic novobiocin. The reaction is activated by ATP [1]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Freel Meyers, C.L., Oberthur, M., Xu, H., Heide, L., Kahne, D. and Walsh, C.T. Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. Angew. Chem. Int. Ed. Engl. 43 (2004) 67–70. [DOI] [PMID: 14694473] |
| 2. |
Gomez Garcia, I., Freel Meyers, C.L., Walsh, C.T. and Lawson, D.M. Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (2008) 1000–1002. [DOI] [PMID: 18997325] |
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| [EC 2.1.3.12 created 2013] |
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