ExplorEnz: EC 2.1.1.56

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2.1.1.56

Accepted name:

mRNA (guanine-N⁷)-methyltransferase

Reaction:

S-adenosyl-L-methionine + a 5′-(5′-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5′-(N⁷-methyl 5′-triphosphoguanosine)-[mRNA]

Glossary:

a 5′-(5′-triphosphoguanosine)-[mRNA] = G5′ppp5′R-[mRNA]
a 5′-(N⁷-methyl 5′-triphosphoguanosine)-[mRNA] = m7G5′ppp5′R-[mRNA] = cap0

Other name(s):

RNMT (gene name); ABD1 (gene name); messenger ribonucleate guanine 7-methyltransferase; guanine-7-methyltransferase; messenger RNA guanine 7-methyltransferase; S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

Systematic name:

S-adenosyl-L-methionine:mRNA (guanine-N⁷)-methyltransferase

Comments:

The terminal N⁷-methylguanosine facilitates gene expression in eukaryotic cells and is recognized by cap-binding proteins.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 56941-25-4

References:

1.	Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. Proc. Natl. Acad. Sci. USA 72 (1975) 2525–2529. [DOI] [PMID: 1058472]
2.	Groner, Y., Gilbao, E. and Aviv, H. Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. Biochemistry 17 (1978) 977–982. [PMID: 629955]
3.	Martin, S.A. and Moss, B. Modification of RNA by mRNA guanylyltransferase and mRNA(guanine-7-)methyltransferase from vaccinia virions. J. Biol. Chem. 250 (1975) 9330–9335. [PMID: 1194287]
4.	Martin, S.A., Paoletti, E. and Moss, B. Purification of mRNA guanylyltransferase and mRNA(guanine-7-)methyltransferase from vaccinia virions. J. Biol. Chem. 250 (1975) 9322–9329. [PMID: 1194286]
5.	Mao, X., Schwer, B. and Shuman, S. Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Mol. Cell Biol. 15 (1995) 4167–4174. [DOI] [PMID: 7623811]
6.	Pillutla, R.C., Yue, Z., Maldonado, E. and Shatkin, A.J. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. J. Biol. Chem. 273 (1998) 21443–21446. [DOI] [PMID: 9705270]
7.	Tsukamoto, T., Shibagaki, Y., Niikura, Y. and Mizumoto, K. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Biochem. Biophys. Res. Commun. 251 (1998) 27–34. [DOI] [PMID: 9790902]

[EC 2.1.1.56 created 1981]