ExplorEnz: EC 2.1.1.348

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2.1.1.348

Accepted name:

mRNA m⁶A methyltransferase

Reaction:

S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N⁶-methyladenine in mRNA

Other name(s):

METTL3 (gene name); METTL14 (gene name)

Systematic name:

S-adenosyl-L-methionine:adenine in mRNA methyltransferase

Comments:

This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W. and He, C. A METTL3-METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation. Nat. Chem. Biol. 10 (2014) 93–95. [DOI] [PMID: 24316715]
2.	Wang, X., Huang, J., Zou, T. and Yin, P. Human m⁶A writers: Two subunits, 2 roles. RNA Biol. 14 (2017) 300–304. [DOI] [PMID: 28121234]

[EC 2.1.1.348 created 2018]