ExplorEnz: EC 2.1.1.285

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2.1.1.285

Accepted name:

demethyldecarbamoylnovobiocin O-methyltransferase

Reaction:

S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin = S-adenosyl-L-homocysteine + decarbamoylnovobiocin

For diagram of novobiocin biosynthesis, click here

Glossary:

demethyldecarbamoylnovobiocin = N-{7-[(6-deoxy-5-methyl-β-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
decarbamoylnovobiocin = N-{7-[(6-deoxy-5-methyl-4-O-methyl-β-D-gulopyranosyl)oxy]4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methyl-2-buten-1-yl)benzamide

Other name(s):

NovP

Systematic name:

S-adenosyl-L-methionine:demethyldecarbamoylnovobiocin 4′′-O-methyltransferase

Comments:

The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Freel Meyers, C.L., Oberthur, M., Xu, H., Heide, L., Kahne, D. and Walsh, C.T. Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. Angew. Chem. Int. Ed. Engl. 43 (2004) 67–70. [DOI] [PMID: 14694473]
2.	Gomez Garcia, I., Stevenson, C.E., Uson, I., Freel Meyers, C.L., Walsh, C.T. and Lawson, D.M. The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily. J. Mol. Biol. 395 (2010) 390–407. [DOI] [PMID: 19857499]

[EC 2.1.1.285 created 2013]