| EC |
2.1.1.239 |
| Accepted name: |
L-olivosyl-oleandolide 3-O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + L-olivosyl-oleandolide = S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide |
| Other name(s): |
OleY |
| Systematic name: |
S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase |
| Comments: |
The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus. It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Rodriguez, L., Rodriguez, D., Olano, C., Brana, A.F., Mendez, C. and Salas, J.A. Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus. J. Bacteriol. 183 (2001) 5358–5363. [DOI] [PMID: 11514520] |
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| [EC 2.1.1.239 created 2012] |
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