ExplorEnz: EC 2.1.1.213

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2.1.1.213

Accepted name:

tRNA (guanine¹⁰-N²)-dimethyltransferase

Reaction:

2 S-adenosyl-L-methionine + guanine¹⁰ in tRNA = 2 S-adenosyl-L-homocysteine + N²-dimethylguanine¹⁰ in tRNA (overall reaction)
(1a) S-adenosyl-L-methionine + guanine¹⁰ in tRNA = S-adenosyl-L-homocysteine + N²-methylguanine¹⁰ in tRNA
(1b) S-adenosyl-L-methionine + N²-methylguanine¹⁰ in tRNA = S-adenosyl-L-homocysteine + N²-dimethylguanine¹⁰ in tRNA

Other name(s):

PAB1283; N(2),N(2)-dimethylguanosine tRNA methyltransferase; Trm-G10; PabTrm-G10; PabTrm-m2 2G10 enzyme

Systematic name:

S-adenosyl-L-methionine:tRNA (guanine¹⁰-N²)-dimethyltransferase

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

Armengaud, J., Urbonavicius, J., Fernandez, B., Chaussinand, G., Bujnicki, J.M. and Grosjean, H. N²-Methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. J. Biol. Chem. 279 (2004) 37142–37152. [DOI] [PMID: 15210688]

[EC 2.1.1.213 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.213)]