EC |
2.1.1.172 |
Accepted name: |
16S rRNA (guanine1207-N2)-methyltransferase |
Reaction: |
S-adenosyl-L-methionine + guanine1207 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA |
Other name(s): |
m2G1207 methyltransferase |
Systematic name: |
S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase |
Comments: |
The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA [1]. The enzyme specifically methylates guanine1207 at N2 in 16S rRNA. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
References: |
1. |
Tscherne, J.S., Nurse, K., Popienick, P. and Ofengand, J. Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli. J. Biol. Chem. 274 (1999) 924–929. [DOI] [PMID: 9873033] |
2. |
Sunita, S., Purta, E., Durawa, M., Tkaczuk, K.L., Swaathi, J., Bujnicki, J.M. and Sivaraman, J. Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC. Nucleic Acids Res. 35 (2007) 4264–4274. [DOI] [PMID: 17576679] |
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[EC 2.1.1.172 created 1976 as EC 2.1.1.52, part transferred 2010 to EC 2.1.1.172] |
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