| EC |
2.1.1.139 |
| Accepted name: |
3′-demethylstaurosporine O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + 3′-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine |
| Other name(s): |
3′-demethoxy-3′-hydroxystaurosporine O-methyltransferase; staurosporine synthase |
| Systematic name: |
S-adenosyl-L-methionine:3′-demethylstaurosporine O-methyltransferase |
| Comments: |
Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 212906-74-6 |
| References: |
| 1. |
Weidner, S., Kittelmann, M., Goeke, K., Ghisalba, O. and Zahner, H. 3′-Demethoxy-3′-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine. J. Antibiot. (Tokyo) 51 (1998) 679–682. [PMID: 9727395] |
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| [EC 2.1.1.139 created 2000] |
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