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Your query returned 1 entry. Printable version
EC | 2.1.1.106 | ||||||||||
Accepted name: | tryptophan 2-C-methyltransferase | ||||||||||
Reaction: | S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + 2-methyl-L-tryptophan (overall reaction) (1a) methylcob(III)alamin + L-tryptophan = cob(I)alamin + 2-methyl-L-tryptophan (1b) S-adenosyl-L-methionine + cob(I)alamin = S-adenosyl-L-homocysteine + methylcob(III)alamin |
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Other name(s): | tsrM (gene name); tryptophan 2-methyltransferase; S-adenosylmethionine:tryptophan 2-methyltransferase | ||||||||||
Systematic name: | S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase | ||||||||||
Comments: | The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. It has an exceptional reaction mechanism as the S-adenosyl-L-methionine (SAM) is not bound to the [4Fe-4S] center and does not produce a 5′-deoxyadenosyl radical but instead is believed to be involved in binding of the L-tryptophan substrate. After transfer of the methyl group from methylcob(III)alaminIn a methyl transfer from SAM to the generated cob(I)alamin takes place, preparing the enzyme for the next catalytic cycle. The original methyl group configuration is preserved. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 126626-83-3 | ||||||||||
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