| EC |
1.8.4.2 |
| Accepted name: |
protein-disulfide reductase (glutathione) |
| Reaction: |
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol |
| Other name(s): |
glutathione-insulin transhydrogenase; insulin reductase; reductase, protein disulfide (glutathione); protein disulfide transhydrogenase; glutathione-protein disulfide oxidoreductase; protein disulfide reductase (glutathione); GSH-insulin transhydrogenase; protein-disulfide interchange enzyme; protein-disulfide isomerase/oxidoreductase; thiol:protein-disulfide oxidoreductase; thiol-protein disulphide oxidoreductase |
| Systematic name: |
glutathione:protein-disulfide oxidoreductase |
| Comments: |
Reduces insulin and some other proteins. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9082-53-5 |
| References: |
| 1. |
Katzen, H.M., Tietze, F. and Stetten, D. Further studies on the properties of hepatic glutathione-insulin transhydrogenase. J. Biol. Chem. 238 (1963) 1006–1011. [PMID: 14031343] |
| 2. |
Kohnert, K.-D., Hahn, H.-J., Zühlke, H., Schmidt, S. and Fiedler, H. Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro. Biochim. Biophys. Acta 338 (1974) 68–77. |
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| [EC 1.8.4.2 created 1965] |
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