| EC |
1.5.1.34 |
| Accepted name: |
6,7-dihydropteridine reductase |
| Reaction: |
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+ |
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For diagram of biopterin biosynthesis, click here |
| Other name(s): |
6,7-dihydropteridine:NAD(P)H oxidoreductase; DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase; NADH-dihydropteridine reductase; NADPH-dihydropteridine reductase; NADPH-specific dihydropteridine reductase; dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase; dihydropteridine reductase; dihydropteridine reductase (NADH); 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase |
| Systematic name: |
5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase |
| Comments: |
The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9074-11-7 |
| References: |
| 1. |
Harano, T. New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin. Insect Biochem. 2 (1972) 385–399. |
| 2. |
Hasegawa, H. Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH. J. Biochem. (Tokyo) 81 (1977) 169–177. [PMID: 191436] |
| 3. |
Kaufman, S. Phenylalanine hydroxylase. Methods Enzymol. 5 (1962) 809–816. |
| 4. |
Lind, K.E. Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines. Eur. J. Biochem. 25 (1972) 560–562. [DOI] [PMID: 4402916] |
| 5. |
Nakanishi, N., Hasegawa, H. and Watabe, S. A new enzyme, NADPH-dihydropteridine reductase in bovine liver. J. Biochem. (Tokyo) 81 (1977) 681–685. [PMID: 16875] |
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| [EC 1.5.1.34 created 1972 as EC 1.6.99.7, modified 1981 (EC 1.6.99.10 created 1978, incorporated 1981), transferred 2003 to EC 1.5.1.34] |
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