| EC |
1.5.1.27 |
| Accepted name: |
1,2-dehydroreticulinium reductase (NADPH) |
| Reaction: |
(R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+ |
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For diagram of thebaine biosynthesis, click here |
| Other name(s): |
1,2-dehydroreticulinium ion reductase |
| Systematic name: |
(R)-reticuline:NADP+ oxidoreductase |
| Comments: |
Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 130590-58-8 |
| References: |
| 1. |
De-Eknamkul, W. and Zenk, M.H. Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings. Phytochemistry 31 (1992) 813–821. |
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| [EC 1.5.1.27 created 1999, modified 2004] |
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