| EC |
1.5.1.2 |
| Accepted name: |
pyrroline-5-carboxylate reductase |
| Reaction: |
L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+ |
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For diagram of proline biosynthesis, click here |
| Other name(s): |
proline oxidase; L-proline oxidase; 1-pyrroline-5-carboxylate reductase; NADPH-L-Δ1-pyrroline carboxylic acid reductase; L-proline-NAD(P)+ 5-oxidoreductase |
| Systematic name: |
L-proline:NAD(P)+ 5-oxidoreductase |
| Comments: |
Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9029-17-8 |
| References: |
| 1. |
Adams, E. and Goldstone, A. Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Δ1-pyrroline-3-hydroxy-5-carboxylate. J. Biol. Chem. 235 (1960) 3499–3503. [PMID: 13681369] |
| 2. |
Meister, A., Radhakrishnan, A.N. and Buckley, S.D. Enzymatic synthesis of L-pipecolic acid and L-proline. J. Biol. Chem. 229 (1957) 789–800. [PMID: 13502341] |
| 3. |
Smith, M.E. and Greenberg, D.M. Characterization of an enzyme reducing pyrroline-5-carboxylate to proline. Nature (Lond.) 177 (1956) 1130. [PMID: 13334497] |
| 4. |
Yura, T. and Vogel, H.J. Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties. J. Biol. Chem. 234 (1959) 335–338. [PMID: 13630905] |
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| [EC 1.5.1.2 created 1961] |
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