ExplorEnz: EC 1.4.1.23

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1.4.1.23

Accepted name:

valine dehydrogenase (NAD⁺)

Reaction:

L-valine + H₂O + NAD⁺ = 3-methyl-2-oxobutanoate + NH₃ + NADH + H⁺

Systematic name:

L-valine:NAD⁺ oxidoreductase (deaminating)

Comments:

The enzyme from Streptomyces spp. has no activity with NADP⁺ [cf. EC 1.4.1.8, valine dehydrogenase (NADP⁺)].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Vancurová, I., Vancura, A., Volc, J., Neuzil, J., Flieger, M., Basarová, G. and Behal, V. Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens. J. Bacteriol. 170 (1988) 5192–5196. [DOI] [PMID: 3182727]
2.	Navarrete, R.M., Vara, J.A. and Hutchinson, C.R. Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). J. Gen. Microbiol. 136 (1990) 273–281. [DOI] [PMID: 2324704]

[EC 1.4.1.23 created 2012]