| EC |
1.3.8.4 |
| Accepted name: |
isovaleryl-CoA dehydrogenase |
| Reaction: |
isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein |
| Other name(s): |
isovaleryl-coenzyme A dehydrogenase; isovaleroyl-coenzyme A dehydrogenase; 3-methylbutanoyl-CoA:(acceptor) oxidoreductase |
| Systematic name: |
3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase |
| Comments: |
Contains a tightly-bound FAD cofactor. Pentanoate can act as donor. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37274-61-6 |
| References: |
| 1. |
Bachhawat, B.K., Robinson, W.G. and Coon, M.J. Enzymatic carboxylation of β-hydroxyisovaleryl coenzyme A. J. Biol. Chem. 219 (1956) 539–550. [PMID: 13319276] |
| 2. |
Ikeda, Y. and Tanaka, K. Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria. J. Biol. Chem. 258 (1983) 1077–1085. [PMID: 6401713] |
| 3. |
Tanaka, K., Budd, M.A., Efron, M.L. and Isselbacher, K.J. Isovaleric acidemia: a new genetic defect of leucine metabolism. Proc. Natl. Acad. Sci. USA 56 (1966) 236–242. [DOI] [PMID: 5229850] |
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| [EC 1.3.8.4 created 1978 as EC 1.3.99.10, modified 1986, transferred 2012 to EC 1.3.8.4] |
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