| EC |
1.3.7.4 |
| Accepted name: |
phytochromobilin:ferredoxin oxidoreductase |
| Reaction: |
(3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXα + 2 reduced ferredoxin |
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For diagram of biliverdin metabolism, click here |
| Other name(s): |
HY2; PPhi B synthase; phytochromobilin synthase |
| Systematic name: |
(3Z)-phytochromobilin:ferredoxin oxidoreductase |
| Comments: |
Catalyses the two-electron reduction of biliverdin IXα. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 138263-99-7 |
| References: |
| 1. |
Frankenberg, N., Mukougawa, K., Kohchi, T. and Lagarias, J.C. Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms. Plant Cell 13 (2001) 965–978. [PMID: 11283349] |
| 2. |
McDowell, M.T. and Lagarias, J.C. Purification and biochemical properties of phytochromobilin synthase from etiolated oat seedlings. Plant Physiol. 126 (2001) 1546–1554. [PMID: 11500553] |
| 3. |
Terry, M.J., Wahleithner, J.A. and Lagarias, J.C. Biosynthesis of the plant photoreceptor phytochrome. Arch. Biochem. Biophys. 306 (1993) 1–15. [DOI] [PMID: 8215388] |
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| [EC 1.3.7.4 created 2002] |
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