| EC |
1.3.3.8 |
| Accepted name: |
tetrahydroberberine oxidase |
| Reaction: |
(S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2 |
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For diagram of canadine biosynthesis, click here and for diagram of columbamine, palmatine and corydaline biosynthesis, click here |
| Other name(s): |
(S)-THB oxidase |
| Systematic name: |
(S)-tetrahydroberberine:oxygen oxidoreductase |
| Comments: |
The enzyme from Berberis sp. is a flavoprotein; that from Coptis japonica is not. (R)-Tetrahydroberberines are not oxidized. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 114705-00-9 |
| References: |
| 1. |
Amann, M., Nagakura, N. and Zenk, M.H. (S)-Tetrahydroprotoberberine oxidase the final enzyme in protoberberine biosynthesis. Tetrahedron Lett. 25 (1984) 953–954. |
| 2. |
Okada, N., Shinmyo, A., Okada, H. and Yamada, Y. Purification and characterization of (S)-tetrahydroberberine oxidase from cultured Coptis japonica cells. Phytochemistry 27 (1988) 979–982. |
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| [EC 1.3.3.8 created 1990 (EC 1.5.3.8 created 1989, incorporated 1992)] |
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