EC |
1.3.1.95 |
Accepted name: |
acrylyl-CoA reductase (NADH) |
Reaction: |
propanoyl-CoA + NAD+ = acryloyl-CoA + NADH + H+ |
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For diagram of 3-(dimethylsulfonio)propanoate metabolism, click here |
Glossary: |
propanoyl-CoA = propionyl-CoA |
Systematic name: |
propanoyl-CoA:NAD+ oxidoreductase |
Comments: |
Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH). |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
References: |
1. |
Hetzel, M., Brock, M., Selmer, T., Pierik, A.J., Golding, B.T. and Buckel, W. Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein. Eur. J. Biochem. 270 (2003) 902–910. [DOI] [PMID: 12603323] |
2. |
Kandasamy, V., Vaidyanathan, H., Djurdjevic, I., Jayamani, E., Ramachandran, K.B., Buckel, W., Jayaraman, G. and Ramalingam, S. Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation. Appl. Microbiol. Biotechnol. 97 (2013) 1191–1200. [DOI] [PMID: 22810300] |
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[EC 1.3.1.95 created 2012] |
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