ExplorEnz: EC 1.3.1.43

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1.3.1.43

Accepted name:

arogenate dehydrogenase

Reaction:

L-arogenate + NAD⁺ = L-tyrosine + NADH + CO₂

For diagram of phenylalanine and tyrosine biosynthesis, click here

Glossary:

L-arogenate = 1-[(2S)-2-amino-2-carboxyethyl]-4-hydroxycyclohexa-2,5-diene-1-carboxylate

Other name(s):

arogenic dehydrogenase (ambiguous); cyclohexadienyl dehydrogenase (ambiguous); pretyrosine dehydrogenase (ambiguous); L-arogenate:NAD⁺ oxidoreductase; arogenate dehydrogenase (NAD⁺)

Systematic name:

L-arogenate:NAD⁺ oxidoreductase (decarboxylating)

Comments:

Arogenate dehydrogenases may utilize NAD⁺ (EC 1.3.1.43), NADP⁺ (EC 1.3.1.78), or both (EC 1.3.1.79). NAD⁺-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC 1.3.1.12, prephenate dehydrogenase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 64295-75-6

References:

1.	Stenmark, S.L., Pierson, D.L., Jensen, R.A. and Glover, G.I. Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway. Nature 247 (1974) 290–292. [PMID: 4206476]
2.	Byng, G.S., Whitaker, R.J., Gherna, R.L. and Jensen, R.A. Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. J. Bacteriol. 144 (1980) 247–257. [PMID: 7419490]
3.	Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. Enzymology of L-tyrosine biosynthesis in corn (Zea mays). Phytochemistry 20 (1981) 1289–1292.
4.	Mayer, E., Waldner-Sander, S., Keller, B., Keller, E. and Lingens, F. Purification of arogenate dehydrogenase from Phenylobacterium immobile. FEBS Lett. 179 (1985) 208–212. [DOI] [PMID: 3967752]
5.	Lingens, F., Keller, E. and Keller, B. Arogenate dehydrogenase from Phenylobacterium immobile. Methods Enzymol. 142 (1987) 513–518. [DOI]
6.	Zamir, L.O., Tiberio, R., Devor, K.A., Sauriol, F., Ahmad, S. and Jensen, R.A. Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. J. Biol. Chem. 263 (1988) 17284–17290. [PMID: 2972718]

[EC 1.3.1.43 created 1989, modified 2003, modified 2005, modified 2015]