| EC |
1.3.1.106 |
| Accepted name: |
cobalt-precorrin-6A reductase |
| Reaction: |
cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+ |
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For diagram of anaerobic corrin biosynthesis (part 2), click here |
| Other name(s): |
cbiJ (gene name) |
| Systematic name: |
cobalt-precorrin-6B:NAD+ oxidoreductase |
| Comments: |
The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of cobalt-precorrin-6A. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. See EC 1.3.1.54, precorrin-6A reductase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Kim, W., Major, T.A. and Whitman, W.B. Role of the precorrin 6-X reductase gene in cobamide biosynthesis in Methanococcus maripaludis. Archaea 1 (2005) 375–384. [PMID: 16243778] |
| 2. |
Moore, S.J., Lawrence, A.D., Biedendieck, R., Deery, E., Frank, S., Howard, M.J., Rigby, S.E. and Warren, M.J. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110 (2013) 14906–14911. [DOI] [PMID: 23922391] |
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| [EC 1.3.1.106 created 2014] |
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