ExplorEnz: EC 1.20.4.2

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1.20.4.2

Accepted name:

methylarsonate reductase

Reaction:

methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H₂O

For diagram of arsenate catabolism, click here

Glossary:

methylarsonite = methylarsonous acid
cacodylic acid = dimethylarsinic acid

Other name(s):

MMA(V) reductase

Systematic name:

methylarsonate:glutathione oxidoreductase

Comments:

The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 254889-62-8

References:

1.	Zakharyan, R.A. and Aposhian, H.V. Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12 (1999) 1278–1283. [DOI] [PMID: 10604879]

[EC 1.20.4.2 created 2000 as EC 1.97.1.7, transferred 2001 to EC 1.20.4.2, modified 2003]