| EC |
1.2.99.8 |
| Accepted name: |
glyceraldehyde dehydrogenase (FAD-containing) |
| Reaction: |
D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor |
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For diagram of the Entner-Doudoroff pathway, click here |
| Other name(s): |
glyceraldehyde oxidoreductase |
| Systematic name: |
D-glyceraldehyde:acceptor oxidoreductase (FAD-containing) |
| Comments: |
The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Kardinahl, S., Schmidt, C.L., Hansen, T., Anemuller, S., Petersen, A. and Schafer, G. The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme—an aldehyde oxidoreductase. Eur. J. Biochem. 260 (1999) 540–548. [DOI] [PMID: 10095793] |
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| [EC 1.2.99.8 created 2013] |
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