ExplorEnz: EC 1.2.1.73

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1.2.1.73

Accepted name:

sulfoacetaldehyde dehydrogenase

Reaction:

2-sulfoacetaldehyde + H₂O + NAD⁺ = sulfoacetate + NADH + 2 H⁺

Glossary:

2-sulfoacetaldehyde = 2-oxoethanesulfonate
taurine = 2-aminoethanesulfonate

Other name(s):

SafD

Systematic name:

2-sulfoacetaldehyde:NAD⁺ oxidoreductase

Comments:

This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD⁺ cannot be replaced by NADP⁺. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

Krejčík, Z., Denger, K., Weinitschke, S., Hollemeyer, K., Pačes, V., Cook, A.M. and Smits, T.H.M. Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase. Arch. Microbiol. 190 (2008) 159–168. [DOI] [PMID: 18506422]

[EC 1.2.1.73 created 2008]