ExplorEnz: EC 1.2.1.32

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1.2.1.32

Accepted name:

aminomuconate-semialdehyde dehydrogenase

Reaction:

2-aminomuconate 6-semialdehyde + NAD⁺ + H₂O = 2-aminomuconate + NADH + 2 H⁺

For diagram of the later stages of tryptophan catabolism, click here

Other name(s):

2-aminomuconate semialdehyde dehydrogenase; 2-hydroxymuconic acid semialdehyde dehydrogenase; 2-hydroxymuconate semialdehyde dehydrogenase; α-aminomuconic ε-semialdehyde dehydrogenase; α-hydroxymuconic ε-semialdehyde dehydrogenase; 2-hydroxymuconic semialdehyde dehydrogenase

Systematic name:

2-aminomuconate-6-semialdehyde:NAD⁺ 6-oxidoreductase

Comments:

Also acts on 2-hydroxymuconate semialdehyde.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37250-95-6

References:

Ichiyama, A., Nakamura, S., Kawai, H., Honjo, T., Nishizuka, Y., Hayaishi, O. and Senoh, S. Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymic formation of α-aminomuconic acid from 3-hydroxyanthranilic acid. J. Biol. Chem. 240 (1965) 740–749. [PMID: 14275130]

[EC 1.2.1.32 created 1972]