| EC |
1.2.1.108 |
| Accepted name: |
alcohol-forming fatty acyl-CoA reductase (NADH) |
| Reaction: |
a long-chain acyl-CoA + 2 NADH + 2 H+ = a long-chain alcohol + 2 NAD+ + CoA |
| Glossary: |
a long-chain acyl-CoA = an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. |
| Other name(s): |
FAR (gene name); long-chain acyl-CoA:NADH reductase |
| Systematic name: |
NADH:long-chain acyl-CoA reductase |
| Comments: |
The enzyme has been characterized from the photosynthetic flagellate Euglena gracilis. The alcohol is formed by a four-electron reduction of fatty acyl-CoA by NADH. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. cf. EC 1.2.1.84, alcohol-forming fatty acyl-CoA reductase (NADPH). |
| Links to other databases: |
BRENDA, EXPASY, GENE, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Kolattukudy, P.E. Reduction of fatty acids to alcohols by cell-free preparations of Euglena gracilis. Biochemistry 9 (1970) 1095–1102. [DOI] [PMID: 4313936] |
| 2. |
Teerawanichpan, P. and Qiu, X. Fatty acyl-CoA reductase and wax synthase from Euglena gracilis in the biosynthesis of medium-chain wax esters. Lipids 45 (2010) 263–273. [DOI] [PMID: 20195781] |
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| [EC 1.2.1.108 created 2025] |
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