ExplorEnz: EC 1.2.1.102

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1.2.1.102

Accepted name:

isopyridoxal dehydrogenase (5-pyridoxate-forming)

Reaction:

isopyridoxal + NAD⁺ + H₂O = 5-pyridoxate + NADH + H⁺

Glossary:

isopyridoxal = 5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carbaldehyde
5-pyridoxate = 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate

Systematic name:

isopyridoxal:NAD⁺ oxidoreductase (5-pyridoxate-forming)

Comments:

The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.1.1.416, isopyridoxal dehydrogenase (5-pyridoxolactone-forming).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B₆ degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936]

[EC 1.2.1.102 created 2018]