| EC |
1.14.99.4 |
| Accepted name: |
progesterone monooxygenase |
| Reaction: |
progesterone + reduced acceptor + O2 = testosterone acetate + acceptor + H2O |
| Other name(s): |
progesterone hydroxylase |
| Systematic name: |
progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating) |
| Comments: |
Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 37256-85-2 |
| References: |
| 1. |
Rahim, M.A. and Sih, C.J. Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain. J. Biol. Chem. 241 (1966) 3615–3623. [PMID: 5950688] |
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| [EC 1.14.99.4 created 1972, modified 1999] |
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