The Enzyme Database

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Accepted name: prostaglandin-endoperoxide synthase
Reaction: arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O
Other name(s): prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase
Systematic name: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Comments: This enzyme acts both as a dioxygenase and as a peroxidase.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 39391-18-9
1.  DeWitt, D.L. and Smith, W.L. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc. Natl. Acad. Sci. USA 85 (1988) 1412–1416. [DOI] [PMID: 3125548]
2.  Ohki, S., Ogino, N., Yamamoto, S. and Hayaishi, O. Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. J. Biol. Chem. 254 (1979) 829–836. [PMID: 104998]
[EC created 1972, modified 1990]

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