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Your query returned 1 entry. 
Printable version
| EC | 1.14.19.72 | ||
| Accepted name: | (–)-pluviatolide synthase | ||
| Reaction: | (–)-matairesinol + [reduced NADPH—hemoprotein reductase] + O2 = (–)-pluviatolide + [oxidized NADPH—hemoprotein reductase] + 2 H2O | ||
| For diagram of podophyllotoxin biosynthesis, click here | |||
| Glossary: | (–)-matairesinol = 3R,4R)-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one (–)-pluviatolide = ((3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
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| Other name(s): | CYP719A23 (gene name) | ||
| Systematic name: | (–)-matairesinol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming) | ||
| Comments: | A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plants Sinopodophyllum hexandrum and Podophyllum peltatum catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
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