ExplorEnz: EC 1.14.19.16

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1.14.19.16

Accepted name:

linoleoyl-lipid Δ¹² conjugase (11E,13Z-forming)

Reaction:

a linoleoyl-[glycerolipid] + 2 ferrocytochrome b₅ + O₂ + 2 H⁺ = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-[glycerolipid] + 2 ferricytochrome b₅ + 2 H₂O

Glossary:

punicate = (9Z,11E,13Z)-octadeca-9,11,13-trienoate
linoleate = (9Z,12Z)-octadeca-9,12-dienoate

Other name(s):

Fac (gene name)

Systematic name:

linoleoyl-lipid,ferrocytochrome-b₅:oxygen 11,14 allylic oxidase (11E,13Z-forming)

Comments:

The enzyme, characterized from the plants Punica granatum (pomegranate) and Trichosanthes kirilowii (Mongolian snake-gourd), converts a single cis double bond at position 12 of linoleate incorporated into phosphatidylcholine into conjugated 11-trans and 13-cis double bonds. cf. EC 1.14.19.33, Δ¹² acyl-lipid conjugase (11E,13E-forming).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Hornung, E., Pernstich, C. and Feussner, I. Formation of conjugated Δ¹¹Δ¹³-double bonds by Δ¹²-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds. Eur. J. Biochem. 269 (2002) 4852–4859. [DOI] [PMID: 12354116]
2.	Iwabuchi, M., Kohno-Murase, J. and Imamura, J. Δ¹²-oleate desaturase-related enzymes associated with formation of conjugated trans-Δ^11, cis-Δ¹³ double bonds. J. Biol. Chem. 278 (2003) 4603–4610. [DOI] [PMID: 12464604]

[EC 1.14.19.16 created 2015]