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Your query returned 1 entry. 
Printable version
| EC | 1.14.15.26 | ||||||||
| Accepted name: | toluene methyl-monooxygenase | ||||||||
| Reaction: | (1) toluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O (2) p-xylene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 4-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O (3) m-xylene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 3-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
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| Glossary: | toluene = methylbenzene p-xylene = 1,4-dimethylbenzene m-xylene = 1,3-dimethylbenzene |
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| Other name(s): | xylM (gene names); ntnM (gene names) | ||||||||
| Systematic name: | methylbenzene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating) | ||||||||
| Comments: | The enzyme, characterized from several Pseudomonas strains, catalyses the first step in the degradation of toluenes and xylenes. It has a broad substrate specificity and is also active with substituted compounds, such as chlorotoluenes. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin—NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. The enzyme can also act on its products, producing gem-diols that spontaneously dehydrate to form aldehydes. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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