EC |
1.14.14.98 |
Accepted name: |
protopine 6-monooxygenase |
Reaction: |
protopine + [reduced NADPH—hemoprotein reductase] + O2 = 6-hydroxyprotopine + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of stylopine biosynthesis, click here |
Other name(s): |
protopine 6-hydroxylase; CYP82N2 (gene name) |
Systematic name: |
protopine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating) |
Comments: |
A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 128561-60-4 |
References: |
1. |
Tanahashi, T. and Zenk, M.H. Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis. Phytochemistry 29 (1990) 1113–1122. |
2. |
Takemura, T., Ikezawa, N., Iwasa, K. and Sato, F. Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells. Phytochemistry 91 (2013) 100–108. [PMID: 22421633] |
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[EC 1.14.14.98 created 1999 as EC 1.14.13.55, transferred 2018 to EC 1.14.14.98] |
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