ExplorEnz: EC 1.14.14.84

Your query returned 1 entry. Printable version

1.14.14.84

Accepted name:

linalool 8-monooxygenase

Reaction:

linalool + 2 [reduced NADPH—hemoprotein reductase] + 2 O₂ = (6E)-8-oxolinalool + 2 [oxidized NADPH—hemoprotein reductase] + 3 H₂O (overall reaction)
(1a) linalool + [reduced NADPH—hemoprotein reductase] + O₂ = (6E)-8-hydroxylinalool + [oxidized NADPH—hemoprotein reductase] + H₂O
(1b) (6E)-8-hydroxylinalool + [reduced NADPH—hemoprotein reductase] + O₂ = (6E)-8-oxolinalool + [oxidized NADPH—hemoprotein reductase] + 2 H₂O

For diagram of acyclic monoterpenoid biosynthesis, click here

Glossary:

linalool = 3,7-dimethylocta-1,6-dien-3-ol

Other name(s):

P-450lin; CYP111

Systematic name:

linalool,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating)

Comments:

A cytochrome P-450 (heme-thiolate) protein found in plants. The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Ullah, A.J., Murray, R.I., Bhattacharyya, P.K., Wagner, G.C. and Gunsalus, I.C. Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase. J. Biol. Chem. 265 (1990) 1345–1351. [PMID: 2295633]
2.	Ropp, J.D., Gunsalus, I.C. and Sligar, S.G. Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita. J. Bacteriol. 175 (1993) 6028–6037. [DOI] [PMID: 8376348]

[EC 1.14.14.84 created 1989 as EC 1.14.99.28, transferred 2012 to EC 1.14.13.151, transferred 2018 to EC 1.14.14.84]