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| EC | 1.14.14.75 | ||
| Accepted name: | fenbendazole monooxygenase (4′-hydroxylating) | ||
| Reaction: | fenbendazole + [reduced NADPH—hemoprotein reductase] + O2 = 4′-hydroxyfenbendazole + [oxidized NADPH—hemoprotein reductase] + H2O | ||
| For diagram of albendazole metabolism, click here | |||
| Glossary: | fenbendazole = methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate 4′-hydroxyfenbendazole = methyl [5-(4-hydroxyphenylsulfanyl)-1H-benzimidazol-2-yl]carbamate albendazole = methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
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| Other name(s): | CYP2C19 (gene name) | ||
| Systematic name: | fenbendazole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4′-hydroxylating) | ||
| Comments: | CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole. | ||
| Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB | ||
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