| EC |
1.14.14.185 |
| Accepted name: |
taxane 9α-hydroxylase |
| Reaction: |
5,20-epoxytax-11-en-4α-ol + [reduced NADPH—hemoprotein reductase] + O2 = 5,20-epoxytax-11-ene-4α,9α-diol + [oxidized NADPH—hemoprotein reductase] + H2O |
| Other name(s): |
taxoid 9α hydroxylase; CYP725A22; T9αOH |
| Systematic name: |
5,20-epoxytax-11-en-4α-ol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (9α-hydroxylating) |
| Comments: |
The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Zhang, Y., Wiese, L., Fang, H., Alseekh, S., Perez de Souza, L., Scossa, F., Molloy, J., Christmann, M. and Fernie, A.R. Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis. Mol. Plant 16 (2023) 1951–1961. [DOI] [PMID: 37897038] |
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| [EC 1.14.14.185 created 2024] |
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