ExplorEnz: EC 1.14.14.171

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1.14.14.171

Accepted name:

β-amyrin 16α-hydroxylase

Reaction:

β-amyrin + [reduced NADPH—hemoprotein reductase] + O₂ = 16α-hydroxy-β-amyrin + [oxidized NADPH—hemoprotein reductase] + H₂O

For diagram of hydroxy-β-amyrin biosynthesis, click here

Glossary:

16α-hydroxy-β-amyrin = olean-12-ene-3β,16α-diol

Other name(s):

CYP87D16

Systematic name:

β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (16α-hydroxylating)

Comments:

A cytochrome P-450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of β-amyrin such as erythrodiol or oleanolic acid.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Moses, T., Pollier, J., Almagro, L., Buyst, D., Van Montagu, M., Pedreño, M.A., Martins, J.C., Thevelein, J.M. and Goossens, A. Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum. Proc. Natl. Acad. Sci. USA 111 (2014) 1634–1639. [PMID: 24434554]
2.	Moses, T., Pollier, J., Faizal, A., Apers, S., Pieters, L., Thevelein, J.M., Geelen, D. and Goossens, A. Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata. Mol. Plant 8 (2015) 122–135. [DOI] [PMID: 25578277]

[EC 1.14.14.171 created 2019]