The Enzyme Database

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Accepted name: β-amyrin 16α-hydroxylase
Reaction: β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = 16α-hydroxy-β-amyrin + [oxidized NADPH—hemoprotein reductase] + H2O
For diagram of hydroxy-β-amyrin biosynthesis, click here
Glossary: 16α-hydroxy-β-amyrin = olean-12-ene-3β,16α-diol
Other name(s): CYP87D16
Systematic name: β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (16α-hydroxylating)
Comments: A cytochrome P-450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of β-amyrin such as erythrodiol or oleanolic acid.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Moses, T., Pollier, J., Almagro, L., Buyst, D., Van Montagu, M., Pedreño, M.A., Martins, J.C., Thevelein, J.M. and Goossens, A. Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum. Proc. Natl. Acad. Sci. USA 111 (2014) 1634–1639. [PMID: 24434554]
2.  Moses, T., Pollier, J., Faizal, A., Apers, S., Pieters, L., Thevelein, J.M., Geelen, D. and Goossens, A. Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata. Mol. Plant 8 (2015) 122–135. [DOI] [PMID: 25578277]
[EC created 2019]

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