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Your query returned 1 entry. Printable version
EC | 1.14.14.168 | ||||
Accepted name: | germacrene A acid 8β-hydroxylase | ||||
Reaction: | germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH—hemoprotein reductase] + O2 = 8β-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH—hemoprotein reductase] + H2O | ||||
For diagram of costunolide, eupatolide and 8-epi-inunolide biosynthesis, click here | |||||
Glossary: | germacra-1(10),4,11(13)-trien-12-oate = germacrene A acid 8β-hydroxygermacra-1(10),4,11(13)-triene-12-oate = 8β-hydroxygermacrene A acid inunolide = germacra-1(10),4,11(13)-trien-12,8β-lactone 8-epi-inunolide = germacra-1(10),4,11(13)-trien-12,8α-lactone |
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Other name(s): | HaG8H; CYP71BL1; CYP71BL6 | ||||
Systematic name: | germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (8β-hydroxylating) | ||||
Comments: | A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8β-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8β) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8α-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8α) (cf. EC 1.14.14.170 8-epi-inunolide synthase). | ||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc | ||||
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