ExplorEnz: EC 1.14.14.159

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1.14.14.159

Accepted name:

dolabradiene monooxygenase

Reaction:

(1) dolabradiene + O₂ + [reduced NADPH—hemoprotein reductase] = 15,16-epoxydolabrene + H₂O + [oxidized NADPH—hemoprotein reductase]
(2) 15,16-epoxydolabrene + O₂ + [reduced NADPH—hemoprotein reductase] = 3β-hydroxy-15,16-epoxydolabrene + H₂O + [oxidized NADPH—hemoprotein reductase]

Glossary:

dolabradiene = (4aS,4bR,7S,8aR,10aS)-7-ethenyl-4b,7,10a-trimethyl-1-methylidenetetradecahydrophenanthrene

Other name(s):

CYP71Z16 (gene name)

Systematic name:

dolabradiene,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3β-hydroxy-15,16-epoxydolabrene-forming)

Comments:

A cytochrome P-450 (heme thiolate) enzyme characterized from maize. The enzyme catalyses the epoxidation of dolabradiene at C-16, followed by hydroxylation at C-3.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

Mafu, S., Ding, Y., Murphy, K.M., Yaacoobi, O., Addison, J.B., Wang, Q., Shen, Z., Briggs, S.P., Bohlmann, J., Castro-Falcon, G., Hughes, C.C., Betsiashvili, M., Huffaker, A., Schmelz, E.A. and Zerbe, P. Discovery, biosynthesis and stress-related accumulation of dolabradiene-derived defenses in maize. Plant Physiol. 176 (2018) 2677–2690. [PMID: 29475898]

[EC 1.14.14.159 created 2018]