The Enzyme Database

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EC 1.14.14.148     
Accepted name: angelicin synthase
Reaction: (+)-columbianetin + [reduced NADPH—hemoprotein reductase] + O2 = angelicin + [oxidized NADPH—hemoprotein reductase] + acetone + 2 H2O
For diagram of psoralen biosynthesis, click here
Other name(s): CYP71AJ4 (gene name)
Systematic name: (+)-columbianetin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase
Comments: This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3′.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Larbat, R., Hehn, A., Hans, J., Schneider, S., Jugde, H., Schneider, B., Matern, U. and Bourgaud, F. Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis. J. Biol. Chem. 284 (2009) 4776–4785. [DOI] [PMID: 19098286]
[EC 1.14.14.148 created 2010 as EC 1.14.13.115, transferred 2018 to EC 1.14.14.148]
 
 


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