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Your query returned 1 entry. 
Printable version
| EC | 1.14.14.131 | ||
| Accepted name: | bursehernin 5′-monooxygenase | ||
| Reaction: | (–)-bursehernin + [reduced NADPH—hemoprotein reductase] + O2 = (–)-5′-demethylyatein + [oxidized NADPH—hemoprotein reductase] + H2O | ||
| For diagram of podophyllotoxin biosynthesis, click here | |||
| Glossary: | (–)-bursehernin = (3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(3,4-dimethoxyphenyl)methyl]oxolan-2-one (–)-5′-demethylyatein = (3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(3-hydroxy-4,5-dimethoxyphenyl)methyl]oxolan-2-one (–)-yaetin = (3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one |
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| Other name(s): | CYP71CU1 (gene name); bursehernin 5′-hydroxylase | ||
| Systematic name: | (–)-bursehernin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (5′-hydroxylating) | ||
| Comments: | A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
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